Liver graft induces the immune tolerance of intestinal allograft in auxiliary en-bloc Hver-small bowel transplantation in pigs
- VernacularTitle:猪肝肠联合移植免疫耐受的实验研究
- Author:
Zhenyu YIN
;
Xiaomin WANG
;
Ning LI
;
Yousheng LI
;
Xiaodong NI
;
Feng JIANG
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Intestinal transplantation;
Immune tolerance;
Pig
- From:
Chinese Journal of Digestive Surgery
2008;7(6):436-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of liver graft on the immune tolerance of intestinal allograft in auxiliary en-bloc liver-small bowel transplantation in pigs.Methods Seventy outbreed Landrace pigs were divided into 4 groups.Ten auxiliary liver-small bowel allotransplantations were performed in group A,B,C,respectively,and 5 segmental small bowel allotransplantatiom were performed in group D.Pigs were administered with routine and lower dose of cyclosporine and methylprednisolone in group B and C,respectively. No immunosuppressive agent was administered to pigs in group A and D.Results The initial time of acute rejection was obviously prolonged in group A than group D.and the acute rejection was milder in group A than group D(P＜0.05).There was no significant difference upon postoperative survival time,initial time of acute rejection and degree of acute rejection between group B and C(P＞0.05).Conclusions The immune tolerance of intestinal allograft Can be induced by liver graft in auxiliary en-bloc liver-small howel transplantation.
