Relationship between the antigenic titer of anti-A(B) IgG in pregnant women and the incidence of hyperbilirubinemia in newborns
- VernacularTitle:孕妇产前IgG抗-A(B)抗原效价与新生儿高胆红素血症发生率关系探讨
- Author:
Xifu LI
- Publication Type:Journal Article
- Keywords:
Gravidity;
Newborns;
Hyperbilirubinemia;
ABO blood type
- From:
Chinese Pediatric Emergency Medicine
2008;15(6):542-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the antigenic titer of anti-A(B) IgG in pregnant women with blood-type O and the incidence of hyperbilirubinemia in newborns with blood-type A or B.Methods The antigenic titer of anti-A(B) IgG were determined in pregnant women with blood-type O whose blood type were incompatible with their mates'.Serological tests for the umbilical blood were analyzed in the neonates with blood-type A or B.The incidence and the pathogenic time of hyperbilirubinemia in newborns were studied by gravidity and test results.Results (1) There was no significant difference in the antigenic titer of anti-A(B) IgG,test results of umbilical blood and the incidence of hyperbilirubinemia between the first and the second pregnancy (P>0.05).(2) With the antigenic titer of anti-A(B) IgG increased,there was significant difference in the positive rate of antibody releasing test to newborns,positive rate of free antibody and the incidence of hyperbilirubinemia (P<0.01).(3) The incidence of hyperbilirubinemia in neonates whose results of antibody releasing test were positive and the antigenic titer of anti-A(B) IgG≤1∶64 were much higher than control group(P<0.01).(4)There was no significant difference in the incidence of hyperbilirubinemia in 3 days after birth (P>0.05).Conclusion The gravidity is not correlative with the antigenic titer of anti-A(B) IgG and the incidence of hyperbilirubinemia in neonates.The risk of hyperbilirubinemia in neonates increases as the antigenic titer of anti-A(B) IgG in gravida ≥1∶32.The incidence of hyperbilirubinemia in neonates become higher as the antigenic titer of anti-A(B) IgG in their mother increasing,however,it has no influence on the onset time of hyperbilirubinemia in newborns.
