Significance of examing carcinoembryonic antigen levels of serum and gastric tissue in patients with precancerous lesions and gastric cancer
- VernacularTitle:胃癌及胃癌前疾病患者血清及组织癌胚抗原检测的意义
- Author:
Min LI
;
Jueping FENG
;
Jing FANG
;
Yaping WANG
- Publication Type:Journal Article
- Keywords:
Stomach ncoplasms;
Carcinoembryonic antigen;
Precancerous lesions;
Serum;
Gmqtric tissue
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(34):13-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To meagure the serum eareinoembryonic antigen(CEA)value and tissue CEA stainingin patients with gastric carcinoma and precancerous lesions,in order to apply the index for the diagnosis and monitoring on gastric carcinoma and precancerous lesions.Methods The gemm CEA level of patients with gastric carcinoma(111 cases),precancerous lesions(167 cases,including chronic atrophic gastritis 104 cases,gastric ulcer 31 cases,mucosa intestinal metaplasia 32 cases)was measured by radioimmunoassay,gastric tissue CEA was measured by immunohistochemical SP staining,and 31 cases with superticial gastritis were admired as controls.Results(1)In patients with gastric carcinoma,the positive rate of tissue CEA(89.2%,99/111)Was higher than that in patients with precancerous lesions[chronic atrophic gastritis 52.9%(55/104),mucosa intestinal metaplasia 53.1%(17/32),gastric ulcer 48.4%(15/31)]and superficial gastritis(19.4%,6/31)(P＜0.01).(2)The positive rate of tissue CEA increased significantly than that of the serum levels in patients with gastric carcinoma and precancerous lesions.(3)The serum CEA level in precancerous lesions showed no significant differences compared with that of superficial gastritis(P＞0.05).Conclusions The tissue CEA could be useful diagnostic and monitoring indicators in patients with gastric carcinoma and precancerous lesions.The serum CEA levels in patients with gastric carcinoma may have value in the diagnosis of gastric carcinoma,but have little value for the precancerous lesions.
