The early diagnosis of myocardial damage in patients with severe head injuries
- VernacularTitle:重型颅脑损伤患者心肌损害的早期诊断
- Author:
Chuanping WU
;
Wendong YANG
;
Huiping GUO
- Publication Type:Journal Article
- Keywords:
severe head injuries;
h-FABP;
myocardial damage;
early diagnosis;
cTnI;
CK-MB;
ECG
- From:
International Journal of Surgery
2008;35(12):810-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective Discusstheinfluence of early diagnosis of myocardial damage and heart-type fatty acid binding protein(h-FABP)on patients with severe head injury after rehabilitation.Methods The sorum h-FABP was detected using enzyme-linked immunosorbent one-step quantitative detection,cTnI using solid-phase enzyme-linked immunosorbent assay(ELISA),CK-MB using the method of immunosuppressive.Results The sorum levels of h-FABP,cTnl and CK-MB in severe head injury patients levels were significantly higher than that of healthy control group(P<0.01),the positive serum h-FABP in severe head injury patients Was significantly higher than cTnI,CK-MB or ECG(P<0.01);8 cases died in47 cases of severe head injury patients,the mortalisty rate was 17.02%(8/47),the mortality rate of abnormal sentrum h-FABP,cTnI and CK-MB group was significantly higher than the normal group(P<0. 01);The serum h-FABP in predicting the death of severe head injury patients was high in sensitivity and negative predictive value,but lower in specificity and accuracy.Condusiom The serum h-FABP quantitative assay as a high-sensitive indicators to minor myocardial dsmage can be used an objective indicators forjudging severity ofacute severe head injury,evaluating incidence of accidents.
