Study of correlation between serum levels of soluble intercellular adhesion molecule-1 and 99Tcm-MDP scintigraphy in patients with rheumatoid arthritis
- VernacularTitle:类风湿性关节炎患者血清可溶性细胞间粘附分子-1测定与核素骨显像相关性研究
- Author:
Wentong LIANG
;
Lifang FAN
;
Jing WANG
;
Zhiqiang JIA
;
Xulei XIE
;
Xiaoyan YAN
;
Lin LI
;
Shiqiang JIA
;
Fengzhen LIU
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Soluble intercellular adhesion molecule-1;
99Tcm-MDP scintigraphy
- From:
Clinical Medicine of China
2008;24(12):1238-1240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and its correlation with accumulation degree of 99Tcm-MDP on bone and arthritis and to study the role of sICAM-1 in the diagnosis of patients with early RA. Methods Serum levels of sICAM-1 were measured by immunoenzymetic assay (ELISA). 99mTc-MDP scintigraphy was carried out for the same patients. The significant test between serum levels of sICAM-1 of three groups was performed with analysis of variance; Correlations between serum levels of sICAM-1 and index of semiquatitive 99Tcm-MDP were obtained using sperman's ranks correlation method. Results Compared with control group,serum levels of sICAM-1 were significantly higher in standard group (group A) (P<0.01) and non-standard group (group B) (P<0.05). No significant difference was found between group A and B(P>0.05). Serum levels of sICAM-1 were positively correlated with 99Tcm-MDP scintigraphy. Most patients of non-standard group and standard group showed visible medium-high uptake of 99Tcm-MDP. While control group had not obviously uptake of 99Tcm-MDP. Conclusion Serum levels of sICAM-1, semiquatitive 99Tcm-MDP scintigraphy, accumulation degree of radiopharmuceuutial on bone and arthritis are helpful for diagnosis of early rheumatoid arthritis and judge-ment of the clinical status and improvement of the prognosis.
