CD4+ CD25+ regulatory T cells prolong islet allografts survival
- VernacularTitle:CD4+CD25+T细胞延长同种异体胰岛移植物存活
- Author:
Mei ZHANG
;
Shuhang XU
;
Yu XU
;
Cuiping LIU
;
Xiaodong MAO
;
Kuanfeng XU
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
T-lymphocytes,regulatory;
Islets of Langerhans transplantation;
Immune tolerance
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):661-663
- CountryChina
- Language:Chinese
-
Abstract:
The potential effect of donor CD4+ CD25+ regulatory T ceLls on the suppression of rejection for allogenetic islet transplantation in vivo was investigated. CD4+ CD25+ regulatory T cells were generated by magnetic activated cell sorting and were ailogeneically transfered with islet transplantation in streptozotocin-induced diabetic BALB/cByJ mice. The results showed that allogeneic CD4+ CD25+ regulatory T cells prolong islet graft survival and normoglycemia in transplanted allogeneic diabetic mice.
