Progress in the mechanisms of glucocorticoid resistance in ectopic ACTH syndrome
- VernacularTitle:异位ACTH综合征的糖皮质激素抵抗机制研究进展
- Author:
Na LI
;
Xiaoying LI
- Publication Type:Journal Article
- Keywords:
ACTH syndrome,ectopic;
Glucocorticoid resistance;
Transcription regulation(Chin J Endocrinol Metab,2008,24:686-688)
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):686-688
- CountryChina
- Language:Chinese
-
Abstract:
High level of eetopie serum ACTH can not be suppressed by endogenous or exogenous glucocorticoid, this is the cardinal characteristic of ectopic ACTH syndrome (EAS), that is to say there exists glucocorticoid resistance in EAS. However, the mechanism of glucocorticoid resistance remains unclear. Identifying the mechanism can help us to diagnose and treat the disease. This review focuses on the mechanism of glucocorticoid resistance from several aspects, including the pre-glucocorticoid receptor (GR), GR and post-GR.
