Effect of doxepin on levels of plasnm motilin and vasoactive intestinal peptide of psychological stress rats
- VernacularTitle:多虑平对心理应激大鼠血浆胃动素与血管活性肠肽水平的影响
- Author:
Xianzhe WU
- Publication Type:Journal Article
- Keywords:
Doxepin;
Psychological stress;
Motilin;
Vasoactive intestinal peptide
- From:Chinese Journal of Behavioral Medicine and Brain Science
2008;17(12):1065-1066
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of doxepin on some gut hormones of psychological stress ratsMethods To stimulate the 6-OHDA.treated rats to attack the experimental rats as social psychological stressor,and to detect the change of levels of plasma motilin(MTL) and vasoactive intestinal peptide(VIP) of experimental rats.Results The level of plasma MTL and VIP of the rats in model group were (318.5±89.37)pg/ml and(65.78±12.10)pg/ml.There were significant difference(P<0.01)between model group and normal group [(223.43+73.05)mg,/mol,(88.27±16.90)me/mol].The level of plasma MTL and VIP of the rats in control group were(267.37±80.33)pg/ml and(77.54±13.36)pg/ml.There were significant difference(P<0.05)between control group and model group. Conclusion Strong psychological stress could influence levels of plasma MTL and VIP of the rats.But Doxepin could adjust the emotional state of psychological stress rats and relieve the effect of psychological stress on levels of plasma MTL and VIP of rats,thus affect gastrointestinal motility.
