Clinical significance of measurement of glycated albumin in impaired glucose regulation and newly diagnosed diabetes
- VernacularTitle:糖化血清白蛋白检测在糖调节受损及新诊断糖尿病人群中的临床意义
- Author:
Junling TANG
;
Xiaojing MA
;
Huijuan LU
;
Jian ZHOU
;
Qing LI
;
Weiping JIA
;
Kunsan XIANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Glycated albumin;
HbA1c
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):630-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of glycated albumin (GA), a parameter in reflecting recent glycemic control, in patients with impaired glucose regulation (IGR) and newly diagnosed diabetes mellitus. Methods From January to June 2007, 516 subjects who accepted oral glucose tolerance test (OGTT) in out-patient department were randomly enrolled, including 130 with normal glucose regulation (NGR), 154 with IGR and 232 with diabetes mellitus. The fasting plasma glucose (FPG), 0.5 h plasma glucose (PG), 1hPG, 2hPG, 3hPG after glucose loading, HbA1c and GA were measured in each subject. The correlation between GA and the other parameters were analyzed. Results There were significant differences in the values of GA among NGR, IGR and diabetes mellitus groups (all P < 0.01), but no difference in the values of HbA1c between NGR group and IGR group (P > 0.05). GA was positively correlated with HbA1c (r = 0.75, P < 0.01). Stepwise regression analysis showed that FPG, 2hPG and body mass index were the major independent contributing factors. Conclusion The combination of plasma glucose with GA measurement may be helpful in evaluating the status of glucose metabolism.
