Hypothalamic-pituitary-adrenal axis in postmenopausal women with type 2 diabetes mellitus and visceral obesity
- VernacularTitle:绝经后2型糖尿病妇女的下丘脑-垂体-肾上腺轴功能改变与腹型肥胖的关系
- Author:
Shengxian LI
;
Wei LIU
;
Lihua WANG
;
Rong HUANG
;
Qi CHENG
;
Yihua WU
;
Yawen CHENG
- Publication Type:Journal Article
- Keywords:
Menopause;
Diabetes mellitus,type 2;
Obesity;
Hypothalamic-pituitary-adrenal axis;
Cortisol
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):633-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of the hypothalamic-pituitary-adrenal (HPA) axis in postmenopausal women with type 2 diabetes and visceral obesity. Methods Subjects were divided into three groups:control group(group C),type 2 diabetes mellitus with non-obesity group (group DM) and type 2 diabetes mellitus with visceral obesity group (group DM + OB). General clinical characteristics, morning blood cortisol concentrations and 24 h urine free cortisol of three groups were compared. Serum cortisol levels were also compared after 0.25 mg dexamethasone suppression test and followed by oral intake of 25 mg cortisone acetate. Results (1) There were no significant differences in basal cortisol levels, but after inhibition with dexamethasone the group DM + OB showed significantly higher cortisol level than that in the control group (P < 0.01). (2) Conversion of oral cortisone to plasma cortisol differed significantly between the group C (lower) and group DM + OB (P < 0.05). (3) Plasma LH and FSH concerntrations were significantly lower in group DM + OB compared with group C (P < 0.01). Conclusion In the postmenopausal women with type 2 diabetes mellitus, the negative feedback mechanism and hepatic 11β-HSD-1 activity were impaired, especially in those with visceral obesity.
