Inhibition of IFN-γ receptor signaling by Hepatitis C Virus non-structural protein NS4B
- VernacularTitle:丙型肝炎病毒非结构蛋白对IFN-γ受体信号的抑制
- Author:
Qinong MO
;
Xiaomei ZHOU
;
Liangquan YAO
;
Zhongxin LI
;
Linli SONG
;
Yuli FENG
;
Yi ZHENG
- Publication Type:Journal Article
- Keywords:
Viral nonstructural proteins/PH/GE;
Hepacivirus/PH/GE;
Receptors,interferon;
Signal transduction
- From:
Journal of Chinese Physician
2008;10(11):1470-1472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of NS4B on host defense system. Methods After cell line stably expressed NS4B was established, cell expression profiling caused by NS4B was studied using DNA microarray, and the results of microarray were verified via IFNGR1 fluorescence intensity analysis. Results The data showed that HCV-NS4B could suppress host defense system-associated gene ex-pression, in particular, IFN-γsignal transduction-related genes. Conclusion NS4B could play a role in persistence and resistance to IFN therapy in HCV infection.
