An epidemiologic survey of hypothyroidism during the first half of pregnancy
- VernacularTitle:妊娠前半期甲状腺功能减退症的临床流行病学调查
- Author:
Yanyan CHEN
;
Weiping TENG
;
Zhongyan SHAN
;
Chenyang LI
;
Weiwei ZHOU
;
Bo GAO
;
Tao SHANG
;
Jiaren ZHOU
;
Bin DING
;
Ying MA
;
Ying WU
;
Qun LIU
;
Wei LIU
;
Xiaohui YU
;
Jia LI
;
Weiwei WANG
;
Yuanbin LI
;
Chenling FAN
;
Hong WANG
;
Rui GUO
;
Hongmei ZHANG
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Hypothyroidism;
Hypothyroxinemia;
Thyroid peroxidase antibodies
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):597-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of hypothyrodism during the first half of pregnancy in the Han nationality women in iodine-adequate area. Methods TSH, FT4 and thyroid peroxidase antibody (TPOAb) levels were detected in 4 800 pregnant women during the first half of pregnancy. Both gestational age-specific reference intervals and population-based reference intervals of thyroid function were applied and the corresponding prevalences of hypothyroidism were compared with each other. Results Based on the gestational age-specific reference intervals, the prevalences of overt hypothyroidism at 4th and 8th weeks of gestation were 1.03%, 0.37% respectively. At 4th, 8th, 12th, 16th and 20th weeks of gestation, the prevalences of subclinical hypothyroidism were 4.59%, 6.15% , 4.68%, 4.53%, 5.96% respectively, while those of hypothyroxinemia were 3.69%, 1.11%, 2.92% , 1.29%, 2.29%, respectively. According to the pepulation-based reference intervals, the rates of missed diagnosis of subclinical hypothyroidism were 0.18%, 2.85%, 4.10%, 3.24%, 3.21% while those of hypothyroxinemia were 3.45%, 0.66%, 2.34%, 1.29%, 1.83%, respectively. During 4th, 8th, 16th weeks of gestation, the positive rates of TPOAb in the group with subclinical hypothyroidism were significantly higher than those with euthyroidism. The prevalences of subclinical hypothyroidism in TPOAb positive group were obviously higher than those in TPOAb negative group at 4th, 8th, 12th, 16th gestational weeks. Conclusion The rates of missed diagnosis of subclinical hypothyroidism and hypothyroxinemia during the first half of pregnancy were decreased by applying the gestational age-specific reference intervals in this prospective study. Positive TPOAb is a risk factor for subclinical hypothyroidism during the first half of pregnancy.
