Comparison of efficacy and safety of three regiments of transient intensive insulin therapy
- VernacularTitle:三种胰岛素强化治疗方案的短期疗效和安全性比较
- Author:
Yan LI
;
Jun LIANG
;
Ying LIANG
;
Shanying LIU
;
Lihong CHEN
;
Chuan YANG
;
Mingtong XU
;
Li YAN
;
Hua CHENG
;
Zuzhi FU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Intensive insulin therapy;
Efficacy;
Safety;
Insulin analogues
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):620-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of three regiments of transient intensive insulin therapy for type 2 diabetes mellitns: thrice preprandial injection of premixed insulin aspart 30, thrice preprandial injection of insulin aspart and injection of glargine at bedtime, thrice preprandial injection of regular insulin and injection of NPH at bedtime. Methods Patients were randomly divided into 3 groups, treated with 3 kinds of intensive insulin therapy. After achieving the target goal, continuous glucose monitoring system was used to compare the blood glucose level, therapeutic time, dosage of insulin, occurrence of hypoglycemia. Results Detected by continuous glucose monitoring system, there was no statistical difference in average blood glucose [(8.3±2.1,7.5±1.9, 6.8±0.8) mmol/L, P > 0.05], blood glucose area under curve 3 hours (AUC1-3) after breakfast, therapeutic time [ (8.3±2.5, 9.1±3.8, 8.4±1.7)d, P > 0.05], dosage of insulin [(0.63± 80%, P > 0.05) among three kinds of transient intensive insulin therapy. There were no patients complaining of hypoglycemic symptom. Conclusion The short-term efficacy and safety among three intensive insulin therapeutic methods are similar. More attention should be paid to monitor the blood glucose during sleep.
