Coronary occlusion by balloon to instruct swine acute myocardial infarction and following ventricualr remodeling model
- VernacularTitle:前降支球囊封堵法建立猪急性心肌梗死后左心室重构模型的研究
- Author:
Jianping ZENG
;
Shenhua ZHOU
;
He HUANG
;
Zhishan SUN
;
Minxing WU
;
Lihua LIU
;
Jianping SUN
;
Liyuan WU
- Publication Type:Journal Article
- Keywords:
Angioplasty,transluminal,pereutaneous coronary;
Disease models,animal;
Myocardial infarction;
Swine
- From:
Journal of Chinese Physician
2008;10(11):1478-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of established swine acute myocardial infarction and following ventricular remodeling model by occluding Coronary with balloon. Methods Ten healthy Domestic swine are enrolled. Each swine's left anterior descending coronary artery was occluded for three hours by dilated balloon, and then reperfusion was performed. During the whole course of operation, the electro-cardiogram was monitored. B-ultrasound and single -photon emission computed tomography examination (SPECT) were performed to detect left ventricular end diastolic dimension, left ventricular tip wall thickness, left ventricular end diastolic volume and left ventricula ejection fraction before operation and one week, three month, six month after acute myocardial infarction. Results Five swine died during the period of opera-tion for lack of experience, the remains survived. Electrocardiogram revealed significant ST-elevation and Q-wave formation. B-untrasound and SPECT witnessed deteriorating left ventricular end diastolic dimension expansion, left ventricular tip wall thickness thinning, left ventricular end diastolic volume expansion and left ventricular ejection fraction depression. Conclusions Coronary artery occlusion by balloon can successfully establish acute myocardial infarction and following left ventricular remodeling models.
