Effects of oxidative stress and podocyte injury in renal injury of hyperthyroidism rats
- VernacularTitle:氧化应激及足细胞损伤在甲状腺功能亢进大鼠肾损害中的作用
- Author:
Huiyao HAO
;
Shengou SUN
;
Xiaoqing MA
;
Yanlin LIU
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Kidney glomerulus/CY;
Hyperthyroidism/CO;
Kidney diseases/ET
- From:
Journal of Chinese Physician
2008;10(11):1486-1490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of oxidative stress, expression change of transforming growth factor-β1 and Nestin in re-nal injury of hyperthyroidism rats. Methods The model of hyperthyroidism rat was made by giving them levothyroxine (L-T4). The activity of SOD, CAT, GSH-Px and the level of MDA on the 25th day, the 45th day, and the 60th day were determined by chromatometry in renal cor-tex.. The expressions of TGF-β1 and Nestin on the 25th day, the 45th day, and the 60th day were determined by immunohistochemistry. Results Along with the course of hyperthyroidism, it showed activity of SOD, CAT, GSH-Px and the expression of Nestin reduced, while the level of MDA and the expression of TGF-β1 increased. Conclusion Oxidative stress can increas the expression of TGF-β1 and podocyte in-jury may played an important role in hyperthyroidism renal injury.
