The study of interleukin-6 and interleukin-18 concentration in patients with metabolic syndrome
- VernacularTitle:代谢综合征与血清IL-18、IL-6关系的研究
- Author:
Li ZHANG
;
Huili LIU
;
Xiaomin XIE
;
Renda LI
;
Bing ZENG
;
Liping YU
;
Haiyan ZHOU
;
Lin LI
;
Jin SHI
;
Xudong NIU
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome X;
Interleukin-6;
Interleukin-18
- From:
Journal of Chinese Physician
2008;10(12):1613-1615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of serum interleukin-6 and interleukin-18 concentration in patients with meta-bolic syndrome (MS), and explore the role of inflammtory markers in these patients. Methods 83 patients with MS were enrolled into study group, among of them, 47 were male and 36 were female, their average was 48.95±10. 17 years. The control group was made of 85 normal volunteers. The levels of fasting blood glucose (FBG), fasting insulin, plasma lipids, interleukin-6 and interleukin-18 were meas-ured in all the patients and normal subjects. The insulin sensitive index was calculated. The levels of the fasting blood inflammatory markers were compared between the two groups. Results Compared with the control group, the HOMA-βof the MS group was significantly de-creased, but the levels of IL-18 and IL-6 were significantly increased. The serum IL-18 levels were positive correlated with FPG, FINS, TG, HOMA-IR, IL-6. Conclusion There are IR and abnormal serum level of IL-18 and IL-6 in patients with MS. It has an intimate association between abnormal serum IL-18 and IR. The inflammatory reaction may play an important role in the development of IR in patients with MS.
