Effects of bone marrow stem cells autologous transplantation on ventricular remodeling after acute myocardial infarction
- VernacularTitle:猪急性心肌梗死后骨髓干细胞自体移植对左心室重构的影响
- Author:
Jianpin ZENG
;
Shenhua ZHOU
;
Ping LIU
;
He HUANG
;
Zhishan SUN
;
Mingxing WU
;
Lihua LIU
;
Jianpin SUN
;
Liyuan WU
;
Zhiliu PENG
;
Ying LIU
;
Yuan LIU
;
Haobo HUANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Stem cell transplantation;
Bone marrow transplantation;
Ventricular remodeling;
Ventricularfunction,left
- From:
Journal of Chinese Physician
2008;10(12):1623-1625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of bone marrow stem cells autologous transplantation on left ventricular remodeling after acute myocardial infarction. Methods Acute myocardial infarction models were successfully established in 10 swines, which were ran-dom divided into two groups, placebo group and trasplantation group. One week after operation, bone marrow stem cells autologous transplan-tation was performed, and control group was administrated with placebo. B-ultrasound and emission computed tomography aexaminations were performed to assess the left ventrieular end diastolic dimension, left ventricular tip wall thickness, left ventricular end diastolic volume and left ventricula ejection fraction before operation, one week, three months after acute myocardial infarction. Results Compared with that of control group, three months after acute myocardial infarction, transplantation group witnessed smaller left ventricular end diastolic dimension, thicker left ventricular tip wall, smaller left ventricular end diastolic volume and higher left ventricular ejection fraction. Conclusions Bone marrow autologous transplantation after acute myocardial infarction can alleviate left ventricular remodeling.
