The effects of γ-IFN on the expression of HLA-G mRNA in primary cultured astrocytoma cells
- VernacularTitle:γ-IFN对星形细胞肿瘤HLA-G mRNA表达的影响
- Author:
Ji ZHONG
;
Xianrui YUAN
;
Zhenwen HE
;
Nianjun REN
;
Hongbo GAO
;
Kai ZHANG
;
Chunxiao JI
- Publication Type:Journal Article
- Keywords:
Interferon type Ⅱ;
Astrocytoma;
HLA antigens
- From:
Journal of Chinese Physician
2008;10(12):1629-1631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of γ-IFN on the expression of HLA-G mRNA in primary cultured astrocytoma cells. Methods Different concentrations of γ-IFN were added to primary cultured cells, and HLA-G mRNA were detected by RT-PCR. Results After γ-IFN treatment, HLA-G mRNA can not be determined from HLA-G originally negative astrocytoma cells. The expression of HLA-G are up - regulated in all original HLA-G positive astrocytoma cells in a dose-dependent manner. Conclusion γ-IFN can increase the ex-pression of HLA-G gene in the primary cultured astrocytoma cells which HLA - G are originally positive.
