Expression of gastrin receptor in HCC cell lines and tissues
- VernacularTitle:胃泌素受体在肝细胞肝癌中的表达
- Author:
Cheng KONG
;
Chunping JIANG
;
Yitao DING
- Publication Type:Journal Article
- Keywords:
Carcinoma hepatocellular;
Gastrin/CCK2 receptor;
Immunohistochemistry
- From:
Chinese Journal of Hepatobiliary Surgery
2008;14(12):881-883
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of gastrin receptor in 4 HCC cell lines and tis-sues and their relation to clinieopathological features. Methods Immunohistochemical staining of GR was performed for the 4 HCC cell lines and the paraffin sections of 25 HCC cases. The relationship be-tween the GR expression in HCC sections and the clinicopatho[ogical parameters were analyzed. Results Positive staining for GR in the 3 HCC SMMC-7721>HepG2>QGY-7701 cell lines and HCC tissues was observed. The expression rate of gastrin receptor was 56 % (14/25). However, there was no association between expression of GR and elinieopathologieal features such as age, gender and clini-cal stage etc except for tumor thrombosis. Concision GR exists in the HCC. Futher study is needed to identify whether GR is a applicable target for endocrine therapy in HCC.
