Angiogenesis and Neurogenesis Promoted by Vascular Endothelial Growth Factor After Cerebral Ischemia
- VernacularTitle:血管内皮生长因子促进脑缺血后血管和神经发生
- Author:
Zhaolu WANG
;
Jiping YANG
;
Xi CHENG
;
Songming CHENG
;
Gelin XU
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
angiogenesis;
neurogenesis;
cerebral ischemia
- From:
International Journal of Cerebrovascular Diseases
2008;16(12):935-938
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor (VEGF) is a powerful angiogeuetic factor. In recent years, it has been found that it has a powerful capacity to promote nerve regeneration, and has potential value in the treatment of ischemic cerebrovascular disease. Newborn endothelial celts can form "vascular niche", and promote neurogenesis by releasing an array of neurotrophic factors. Also, newborn neuronal cells can enhance angiogenesis. There is a "cross-talk" between angiogenesis and neurogenesis, and VEGF plays a very important intermediary role in it. This article reviews the studies of VEGF in promoting angiogenesis and neurogenesis after cerebral ischemia.
