Lectin-Like Oxidized Low-Density-Lipoprotein Receptor-1 and Atherosclerosis
- VernacularTitle:血凝素样氧化型低密度脂蛋白受体-1与动脉粥样硬化
- Author:
Dongsheng LI
;
Yunhai LIU
- Publication Type:Journal Article
- Keywords:
lectin-like oxidized low-density lipoprotein receptor-1;
oxidized low-density lipoprotein;
atherosclerosis;
gene polymorphism
- From:
International Journal of Cerebrovascular Diseases
2008;16(12):939-942
- CountryChina
- Language:Chinese
-
Abstract:
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a specific receptor of oxidized low-density lipoprotein (oxLDL) expressed in endothelial cells. It is a type Ⅱ single-chain transmembrane protein and belongs to C-type lectin family. LOX-1 leads to the injury of endothelial cells by mediating oxLDL, and plays a role in the initiation and progression of atherosclerosis, hypertension, thrombosis. This article reviews the association between LOX-1 and atherosclerosis.
