Evaluation of effects of simvastatin on vascular elasticity in fat-fed rabbits by echo-tracking technique
- VernacularTitle:血管回声跟踪技术评价辛伐他汀对高脂喂养兔血管弹性的影响
- Author:
Li XU
;
Baozhong SHEN
;
Shijia YU
;
Tiemei SHI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Aorta,abdominal;
Femoral artery;
Elasticity
- From:
Chinese Journal of Ultrasonography
2008;17(12):1072-1075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of simvastatin on the vascular elasticitv in fat-fed rabbits by echo-tracking(ET)technique.Methods Twenty seven rabbits were divided randomly into 3 groups:normal control group(group A),high fat diet group(group B),simvastatin group(group C:high fat diet for the 1st 4 weeks and high fat diet+simvastatin for the 2nd 4 weeks).β,EP,AC,and PWVβof abdominal aorta (AO) and femoral artery(FA)of rabbits in group A、B、C were measured by ET technique at the end of 4th week and 8th week respectively.The expression of iNOS was measured at the end of 8th week.Results At the end of the 4th week,β,Ep,and PWVβ of FA were significantly inereased and AC was significantly decreased in group B compared to those in group A(P＜0.05).At the end of the 8th week,β,Ep,PWVβof AO were significantly increased and AC was significantly decreased in group B compared to those in group A(P＜0.05);β,Ep,PWVβ of FA were statistically decreased and AC was statistically increased in group C compared to those in group B(P＜0.05),however there was no significant difference of AO between groups B and C.Conclusions Short-term administration of simvastatin can improve the elasticity of some muscular arteries such as FA but not AO.
