Expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in synovium of collagen-induced arthritis and its correlation with angiogenesis

VernacularTitle:缺氧诱导因子-1α血管内皮生长因子在胶原诱导性关节炎滑膜中的表达及其与血管生成的关系
Author: Lie DAI ; Chencheng DAI ; Baiyu ZHANG ; Donghui ZHENG ; Haijun LIU
Publication Type:Journal Article
Keywords: Arthritis,experimental; Hypoxia-indueible factorl; Angiogenesis; Vascular endothelial growth factor
From: Chinese Journal of Rheumatology 2009;13(1):20-22
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of hypoxia-inducible factor (HIF)-1α and vascular en-dothelial growth factor (VEGF) on the angioge-nesis of rheumatoid arthritis (RA). Methods The collagen-induced arthritis (CIA) model was set up in male Wistar rats. The pathological angiogenesis and expression of HIF-1α and VEGF in the synovia different time points were observed by H&E and immunohistochemistry staining. Results The expressions of HIF-1α and VEGF on CIA synovium were significantly elevated and their expression increased gradually with the prolonged disease course. Both synovial HIF-1α expression and VEGF expression were correlated significantly with the pathological angiogenesis score. Synovial lining and sublining HIF-1α expression were correlated significantly with VEGF expression respectively. Conclusion H1F-1α may play an important role in the pathogenesis of RA by upregulating the expression of VEGF and then promoting angiogenesis.