The diagnostic value of anti-mutated citrullinated vimentin, anti-cyclic citrullinated peptide and glucose-6-phosphateisomierase for rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2009.01.027
- VernacularTitle:抗突变型瓜氨酸波形蛋白抗体葡萄糖-6-磷酸异构酶和抗环瓜氨酸多肽抗体检测在类风湿关节炎诊断中的价值
- Author:
Lijun WU
;
Qingli LU
;
Xinjie SHAN
;
Xiaoyun SONG
;
Xinyan MENG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Anti-mutated citrullinated vimentin antibody;
Anti-cyclic citrul-linated peptide antibody;
Glucose-6-phosphateisomerase
- From:
Chinese Journal of Rheumatology
2009;13(1):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objeictivie To investigate the diagnostic value of anti-mutated citrullinated vimentin (anti-MCV) antibody, anti-cyclic citrullinated peptide (anti-CCP) antibodies and glucose-6-phospha-teisomerase (GP1) for rheumatoid arthritis (RA). Methods Anti-MCV antibody, GPI and anti-CCP antibody were detected in serum samples of 109 RA patients, 24 non-RA rheumatic diseases patients and 19 healthy blood donors. The sensitivity and specificity of these parameters for the diagnosis of RA were analyzed. Results Both the positive rate and average cut off concentration of anti-MCV and GPI in RA were higher than those of non-RA rheumatic diseases or healthy controls (P<0.05). A significant difference was found between anti-MCV and GPI in RA patients. The most sensitive and specific parameter in RA was anti-MCV (99.1%) and anti-CCP (90.7%) respectively, but, when anti-MCV combined with anti-CCP, or GPI or anti-CCP and GPI, the specificity could be up to 98.1%. Coniclusions Anti-MCV, anti-CCP and GPI alone or in combination may be valuable parameters for the diagnosis of RA.
