Diffuse large B-cell lymphoma:clinical feature and outcome of the Waldeyer's ring versus nodal presentation
10.3760/cma.j.issn.1004-4221.2009.01.007
- VernacularTitle:韦氏环和结内弥漫性大B细胞淋巴瘤的临床特征与预后
- Author:
Shunan QI
;
Yexiong LI
;
Qingfeng LIU
;
Hui FANG
;
Hua WANG
;
Jing JIN
;
Weihu WANG
;
Yongwen SONG
;
Shulian WANG
;
Yueping LIU
;
Xinfan LIU
;
Zihao YU
- Publication Type:Journal Article
- Keywords:
Lymphoma,B-cell;
Lymphoma,large-cell,diffuse;
Lymphoma,nodal;
Lympboma,extranodal
- From:
Chinese Journal of Radiation Oncology
2009;18(1):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze clinical characteristics of diffuse large B-cell lymphonma(DL BCL) of Waldeyer's ring(WR-DLBCL) comparing with those of nodal DLBCL(N-DLBCL).Methods 181 patients consecutively diagnosed as primary WR-DLBCL(80) or N-DLBCL(101) were retrospectively reviewed.According to Ann Arbor staging system,57,83,26 and 15 patients had stage Ⅰ ,Ⅱ ,Ⅲ and Ⅳ disease,respectively.Patients with stageⅠ-Ⅱ disease were treated with chemotherapy and radiotherapy, whereas patients with stage Ⅲ-Ⅳ disease received primary chemotherapy. Results Comparing with N-DL BCL,pafients with WR-DLBCL presented with more stage Ⅱdiseases,more frequent involvement of adjacent organs and tissues,less B-symptoms,less involvement of spleen and lower lactate dehydrogenase (LDH) and β2-microglobulin(β2M) level.The 5-year overall survival(OS) rate of all patients was 76% for WR-DLBCL and 56% for N-DLBCL(x2 =2.43,P=0.119) ,respectively.The corresponding OS rate for stage Ⅰ and Ⅱ diseases was 78% for WR-DLBCL and 58% for N-DLBCL(X2 = 2.76,P =0.097),respectively.On univa riate analysis,elevated LDH,IPI and elevated β2 M were prognostic predictors for WR-DLBCL patients, whereas elevated β2 M,bulky tumor and IPI were associated with poor OS for N-DLBCL patients.On multiva riate analysis,elevated LDH and β2M were prognostic predictors for all patients. Conclusions Comparing with N-DLBCL,WR-DLBCL represents distinct clinical features and prognosis.
