Expression and clinical significance of ku7O in nasopharyngeal carcinoma
10.3760/cma.j.issn.1004-4221.2009.01.033
- VernacularTitle:Ku70蛋白在鼻咽癌中的表达及其临床意义
- Author:
Shanshan YAN
;
Zhigang LIU
;
Li LIU
;
Libing SONG
;
Musheng ZENG
;
Yunfei XIA
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
KuT0;
DNA double-strand break;
Immunohisto chemistry
- From:
Chinese Journal of Radiation Oncology
2009;18(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Ku70 in nasopha ryngeal oarcinoma(NPC).Methods The expression of Ku70 protein in 223 specimens of nasopharyngeal carcinoma was examined by immunohistochemistry.Based on the levels of ku70 immunoreactivities,the 223 specimens were divided into high Ku70 expression group and low Ku70 expression group.The correlation of Ku70 expression with clinicopathologic features and prognosis of NPC was analyzed according to the clinical data. Results The rate of high Ku70 expression was 63.7%.Univariate survival analysis suggested that the overall survival rate was significantly lower in high KuTO expression group than in low Ku70 expression group (X2 = 7.88,P = 0.005).Cox multivariate analysis indicated that T stage,N stage and M stage were the independent prognostic predictors (X2 = 8.02,7.22,36.86;P =0.005,0.007,0.000),but not with gender, age or pathological type(X2 = 0.08 ,1.04,2.34;P = 0.780,0.308,0.126),the influence of Ku70 on the o verall survival rate was close to critical value(P = 0.085).Conclusions Ku70 is positively expressed in the majority of NPC.KuT0 expression has significant correlations with T stage and N stage.The results of our study suggest that Ku70 is a valuable prognostic factor of NPC.
