The changes of plasma levels of cytokines in patients of hypoxic-ischemic encephalopathy and its clinical significance
- VernacularTitle:缺氧缺血性脑病患儿血浆细胞因子变化及临床意义
- Author:
Zhiling ZHAO
;
Weiyuan ZHANG
;
Mei GU
;
Qi WANG
- Publication Type:Journal Article
- Keywords:
Hypoxia-ischemia,brain;
Interleukin-6;
Interleukin-8;
Tumor necrosis fac-tor-alpha
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(36):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of cytokines on the pathogenesis of hypoxic-ischemic en-cephalopathy (HIE). Method The levels of peripheral blood interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) in 40 HIE and 40 healthy neonates were detected at the 1st, 3rd and 7th day after birth by using radioimmunoassay. Results Compared with healthy neonates, at the 1 st, 3rd after birth, the level of peripheral blood IL-6 was decreased [(52.3±24.5)ng/L vs (80.1±28.6)ng/L and (56.9±28.5) ng/L vs (78.6±28.9)ng/L, respoctively], but IL-15 and TNF-α were increased [IL-8:(0.68±0.23)ng/L vs (0.47±0.13)ng/L and (0.63±0.22)ng/L vs (0.40±0.16)ng/L, TNF-α: (1.17±0.30)ng/L vs (0.91± 0.30) ng/L and (1.14±0.29)ng/L vs (0.96±0.34)ng/L]in HIE infants. Conclusion The changes of plas-ma levels of IL-6, IL-8 and TNF-α in neonatal HIE possibly play an important role in the pathophysiologic mechanisms of HIE.
