Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp
10.3760/cma.j.issn.0578-1426.2009.01.005
- VernacularTitle:经典1型糖尿病患者胰岛素抵抗的高胰岛素正葡萄糖钳夹研究
- Author:
Guochun LUO
;
Zhen LIANG
;
Qinghong HU
;
Dewen YAN
;
Lingbo LU
;
Wenhui GU
;
Zelong CHEN
;
Haiyan LI
;
Mingming LIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 1;
Insulin resistance;
Euglycemic-hyperinsulinemic clamp technique
- From:
Chinese Journal of Internal Medicine
2009;48(1):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate insulin resistance in type 1 diabetes(T1DM)with euglycemic-hyperinsulinemic clamp.Methods Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes(T2DM)were selected.Their insulin sensitivity index(ISI)was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 heMthy volunteers(normal control group,NC group).Results Age,BMI,fasting insulin(Fins),fasting C-peptide in the TI DM group were significantly lower than those in the NC group.while waist-to-hip ratio (WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),TC,TG,LDL-C,HDL-C were not significantly different between the T1DM and NC groups.Age,BMI,WHR,Fins,fasting C-peptide,SBP,TC,TG in the T1DM group were significantly lower than those in the T2DM group.The ISI of the NC,TlDM and T2DM groups were 12.83±1.09,9.95±0.50,3.80±0.20,respectively.There was significant difference among the three groups(P＜0.05).Conclusion The ISI in T1DM Was significantly lower than that in NC group,but higher than that in T2DM.
