Survey of cognitive function in motor neuron disease

VernacularTitle:运动神经元病患者认知功能筛查
Author: Fei GAO ; Dongsheng FAN ; Huali WANG ; Qiong YANG ; Yan ZHANG ; Jun ZHANG ; Yang SHEN
Publication Type:Journal Article
Keywords: Motor neuron disease; Cognition disorders; Dementia
From: Chinese Journal of Internal Medicine 2009;48(1):31-34
CountryChina
Language:Chinese
Abstract: Objective The aim of the study is to investigate the prevalence of cognitive impairment and frontotemporal dysfunction in Chinese patients with motor neuron disease(MND).Methods 100 Datients diagnosed as MND underwent a series of survey including mini mental state examination(MMSE),neuropsychiatry inventory(NPI),Hamilton depression scale(HAMD)and Hamilton anxiety scale (HAMA).Demographics,site of onset,and disease severity-functional rating scale(FRS)were also investigated.Results The prevalence of mild cognitive impairment determined with MMSE score was 24.2%.Compal ison between patients with normal and abnormal MMSE showed statistic differences in depression state and FRS score.Since patients with anxiety and depression would also have abnormal NPI,a follow uP stndy after 3-month antidepressive therapy for the depression patients was made and 2 patients were found to haye Drobably frontotemporal dysfunction lasting for more than 6 months.Conclusion MND patients might have mild impairmented of cognitive function and some of the patients were neuroethologically abnormal.2 of the patients might have frontotcmporal dysfunction.