Modulatory effect of Rho kinase on the cerebral vasospasm following subarachnoid hemorrhage
- VernacularTitle:蛛网膜下腔出血后RHO激酶影响脑血管痉挛的初步研究
- Author:
Maohua CHEN
;
Jun SUN
;
Chuan LU
;
Xiandong CHEN
;
Jianyong CAI
;
Huajun BA
;
Jianhu LIN
;
Xuexiong HE
- Publication Type:Journal Article
- Keywords:
Protein-serine-threonine kinase;
Vasospasm,intracranial;
Subarachnoid hemorrhage
- From:
Journal of Chinese Physician
2008;10(12):1605-1607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamical changes of Rho kinase in the cerebrospinal fluid (CSF) and its relationship with cerebral vascular spasm CVS. Methods CSF were collected on the ist, 3rd, 7th, 10th and 14th day after subarachnoid hemorrhage. The expression of Rho-kinase mRNA in CSF was determined by RT-PCR. The expression of endothelin-1 in CSF was determined by radioimmuno-assay. TCD was used to measure the velocity of the cerebral artery. Results The levels of ET-1 and Rho-kinase mRNA in CSF were re-markably increased on the 3rd day, and reached at the peak on the 7th day after subarachnoid hemorrhage, which were significantly higher than those without CVS. Conclusion There is a positive correlation between the level of Rho-kinase mRNA and ET-1 in CSF. Rho-kinase may participate in the development of CVS.
