The Molecular Mechanisms of Ubiquitin-Proteasome System Effecting on Cognition
- VernacularTitle:泛素-蛋白酶体系统影响认知功能的分子机制
- Author:
Zhang HAO
;
Hai JIAN
- Publication Type:Journal Article
- Keywords:
ubiquitin-proteasome system;
cognitive fumtion;
molecular mechanism
- From:
International Journal of Cerebrovascular Diseases
2008;16(11):862-865
- CountryChina
- Language:Chinese
-
Abstract:
As a highly efficient protein degradation pathway,ubiquitin-proteasome system(UPS) plays an important role in maintaining cell function.The role of UPS is becoming a new research focus in molecular mechanism of cognitive function.UPS mainly acts on neurotrans mitter and its receptor,synaptic reguIation,long-term potentiation of postsynaptic poteraiais and neuronal signal transduction,and it may become a new target for the intervention of cognitive dysfunction.
