Relations of matrix metalloproteinases and tumor microenvironment
- VernacularTitle:基质金属蛋白酶与肿瘤微环境的关系
- Author:
Jing GUO
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Extracellular matrix;
Neoplasm metastasis
- From:
Journal of International Oncology
2008;35(11):810-812
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteases(MMPs)and tissue inhibitors of matrix metalloproteases(TIMPs) have a co-regulation of changes of the extraeellular matrix(ECM).MMPs can control the proteases which are related to the process of tumor development.Moreover,MMPs,produced by host cells including inflammatory ceUs,endothelial cells,pericytes and fibroblasts have a positive or negative correlation with tumor formation.
