Magnetic resonance imaging appearance of neuromyelitis optica in spinal cord

VernacularTitle:视神经脊髓炎脊髓磁共振成像特征
Author: Zhengqi LU ; Kefeng Lü ; Xueqiang HU ; Yan ZOU ; Cansheng ZHU ; Wenxia YOU
Publication Type:Journal Article
Keywords: Neuromyelitis optica; Multiple sclerosis; Aquaporin 4; Magnetic resonanceimaging
From: Chinese Journal of Neurology 2009;42(1):15-19
CountryChina
Language:Chinese
Abstract: Objective To investigate the characteristic MRI appearance of neuromyelitis optics (NMO) and muhip]e sclerosis (MS) in the spinal cord.Methods Twenty cases of MS and 23 cases of NMO were examined by MRL All image appearances were analyzed.Results The characteristic MRI appearance of NMO patients in the spinal cord was linear medullary lesion (LML), linear medullospinal lesion (LMSL), linear spinal lesion (LSL) and longitudinally extensive transverse myelitis (LETM), and spinal cord MRI with contiguous T2-weighted signal abnormality extending over 3 or more vertebral segments (23 cases), while in MS, spinal cord MRI with contiguous T2-weighted signal abnormality often extended less than 3 vertebral segments (only 12 cases, χ2 = 19.142, P < 0.01), and the distribution of spinal lesion usually was eccentric (17 cases, compared with NMO group, χ2 = 25.256, P < 0.01).Conclusions NMO is distinct from MS.In MRI, spinal lesion in NMO usually conforms to the distribution of aquaporin 4, while spinal lesion in MS always conforms to the demyelination.NMO has neuroimaging features that move it ever closer to distinct disease status.