Role of circulating immune complex in aspirin-sensitive asthma.
- Author:
Hae Sim PARK
1
;
Dong Ho NAHM
Author Information
1. Department of Allergy, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article
- MeSH:
Adult;
Aged;
Antigen-Antibody Complex/blood*;
Aspirin/adverse effects*;
Asthma/immunology*;
Asthma/etiology*;
Asthma/complications;
Case-Control Studies;
Human;
IgA/blood;
IgG/blood;
Middle Age;
Nasal Polyps/etiology
- From:The Korean Journal of Internal Medicine
1998;13(1):51-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND & OBJECTIVES: The pathogenic mechanism of aspirin-sensitive asthma (ASA-BA) remains to be further defined. To evaluate the role of circulating immune complex (CIC) in ASA-BA. SUBJECTS & METHODS: We measured IgG- and IgA-IC level by ELISA using anti-C3 antibody in 33 ASA-BA patients whose sensitivity was confirmed by lysine-aspirin bronchoprovocation test, and compared with those of 14 allergic, 14 intrinsic asthma patients and 7 healthy controls. RESULTS: There was no significant difference in IgG-IC level among the four groups (p > 0.05), while IgA-IC levels of aspirin-sensitive asthma were higher than those of other groups (p = 0.0035). Patients with nasal polyp had significantly higher IgG-IC than those without it (p = 0.02). No differences were found according to medication and symptom scores, and presence of atopy, rhino-sinusitis, urticaria or concurrent sensitivity to sulfite (p > 0.05). Insignificant correlation was found between IgG-IC level and asthma duration, total IgE level, or circulating eosinophil count. CONCLUSION: These findings suggest a possible contribution of IgG-IC to the development of nasal polyp in ASA-BA. Further study will be needed to clarify the role of IgA-IC in the pathogenesis of ASA-BA.
