Late local-regional recurrence of nasopharyngeal carcinoma after conventional radiotherapy
10.3760/cma.j.issn.1004-4221.2009.01.030
- VernacularTitle:62例鼻咽癌常规放疗5年后局部区域复发的再程常规放疗分析
- Author:
Derui LI
;
Dongsheng LI
;
Zhijian CHEN
;
Chuangzhen CHEN
;
Mingzhen ZHOU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms/radiotherapy;
Neoplasms recurrence,local-regional;
Second treatment;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2009;18(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the local-regional recurrence of nasopharyngeal carcinoma (NPC) 5 years after conventional radiotherapy and its prognosis.Methods From August 1989 to Decem ber 1999,1384 patients with newly histo-pathologicatly diagnosed NPC were treated with conventional radia tion.350 out of 1277 followed-up patients were diagnosed as local-regional failure.The intervals between completion of radiation and tumor relapse ranged from 6 months to 171 months.There were 62 patients with local-regional recurrence 5 years after the radiotherapy,including 41 in nasopharynx,19 in neck and 2 in na sopharynx and neck simultaneously.Thirty-seven patients with late local-regional recurrence received a sec ond course conventional radiotherapy.Results The median survival time was 44 months(95% CI = 30.4 -57.6) of patients with re-irradiation comparing with 14 months (95% CI = 7.1-20.8) of those without. The 5 year survival rate after re-irradiation was 42%.Conclusions Local-regional recurrence of nasopha ryngeal carcinoma can oeoure 5 years after radiotherapy.Second course converntional radiotherapy possesses good results.
