Relationship betwwen epidermal growth factor, residual and curative effect in patients with nasopharyngeal cancer
- VernacularTitle:表皮生长因子受体表达、肿瘤残留与鼻咽癌疗效的关系
- Author:
Yuhong LAN
;
Li BAI
;
Huimin MA
;
Xiuhua PAN
;
Qingxu YANG
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal;
Radiotherapy;
Chemotherapy;
Epidermal growth factor receptor;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):1962-1963
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate epidermal growth factor receptor(EGFR)expression and tumor residual to the prognostic value in patients with nasopharyngeal cancer(NPC).Methods 200 patients with NPC were examined for EGFR expression by immunohistochemistry analysis,neck cancer and nasopharyngeal residual.Results In 200 cases with NPC,expression of EGFR of positive and negative were 160 cases(80.0%) and 40 cases (20.0%);the rate of overall survival(OS),disease-free survival (DFS),loeoregional relapse-free survival (LRFS) and distant metastasis-free survival(DMFS)in patients with positive EGFR were 72.3%,63.6%,72.2%,63.8% and negative EGFR were 90.0%,90.0%,90.0%,90.0%,respectively in 3-year(X2=3.95,X2=4.12,X2=3.98,X2=4.15,P＜0.05),the rate of local recurrence,distant metastasis rate in residual were 26.6%,32.5% which is significantly higher than 8.1%,18.1% in without residual(X2=4.75,X2=4.94,P＜0.05);the hish expression of EGFR with DFS,OS were significantly correlated(r=6.457,P＜0.05).Conclusion The overexpress of EGFR had the tendency of poor prognosis.tumor residual after radiotherpy can be a prognostic indicator for patients with NPC.
