Relationship between adipose cytokines and metabolic syndrome in newly diagnosed type 2 diabetes mellitus patients
10.3760/cma.j.issn.0254-9026.2009.01.007
- VernacularTitle:新诊断2型糖尿病患者脂肪细胞因子水平与代谢综合征的关系
- Author:
Qi PAN
;
Lixin GUO
;
Lei JIANG
;
Mingxiao SUN
;
Ming LI
;
Xiaoping LIU
;
Yao WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Adiponectin;
Retinol-binding proteins;
Metabolic syndrome X
- From:
Chinese Journal of Geriatrics
2009;28(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum levels of adiponectin (APN) and retinol binding protein 4 (RBP4) in newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods 95 newly diagnosed T2DM patients and 55 non-diabetic volunteers from health examination population were studied. The serum concentrations of APN and RBP4 were determined by ELISA. The levels of plasma glucose, lipid profiles and insulin were also measured in fasting samples. Insulin sensitivity was assessed by insulin resistance index (HOMA-IR). The control group and diabetic group were divided into ≥60 years subgroup and <60 years subgroup respectively. According to the guideline designed by Chinese Diabetes Society(CDS)in 2004, the control group and diabetic group were divided into different kinds of abnormal metabolism groups. Results (1)The level of APN was significantly decreased in diabetic group compared with the control group[(7.26±4.69)mg/L vs. (11.93±4.89)mg/L], while the serum level of RBP4 in diabetic group was obviously higher than that in control group[(16.48±7.82) mg/L vs. (10.91±5.26) rag/L]. (2) The prevalence of metabolic syndrome in diabetic group was higher than that in control group (46.3% vs. 7.3%). (3)APN level was decreased with the increasing number of components of MS, and RBP4 level was increased with the increasing number of components of MS. (4) In DM group, APN level was correlated negatively with MS, waist circumference and BMI, and RBP4 level was correlated positively with waist circumference, HOMA-IR, BMI and TG. Conclusions APN and RBP4 levels are significantly associated with metabolic syndrome. Hypoadiponectinemia and higher retinal binding protein 4 may play an important role in the pathogenesis of MS.
