A case-control study on postoperative cognitive dysfunction induced by patient-controlled intravenous analgesia in elderly patients

VernacularTitle:患者自控静脉镇痛引起老年人术后认知功能障碍的病例对照研究
Author: Wenfei TAN ; Chunyu AI ; Bo BANG ; Hong MA ; Junke WANG
Publication Type:Journal Article
Keywords: Analgesia,patient controlled; Postoperative complications; Cognition disorders; Risk factors
From: Chinese Journal of Geriatrics 2009;28(1):42-44
CountryChina
Language:Chinese
Abstract: Objective To investigate the risk factors for postoperative cognitive dysfunction (POCD)induced by patient-controlled intravenous analgesia(PCIA)in elderly patients. Methods 95 patients with POCD and 97 cognitive normal controls were included in the study. The cases and controls were matched for gender, type of operation and PCIA volume dose. Cognitive function was assessed by Mini-Mental-State test and the relationship between POCD and various factors was analyzed by univariate and multivariate analysis. Results Univariate analysis revealed that the education level and visual analog scale (VAS) score had significant differences between the two groups. Multivariate analysis showed that the VAS score and education level were significantly related to POCD induced by PCIA, with the odds ratios of 2. 379 (95%CI:1.205～4.698) and 0. 292 (95%CI:0.157～0.543), respectively. Conclusions Lower VAS score is an independent risk factor and higher education level seems to be a protective factor for POCD induced by PCIA.