Dyslipidemia in primary Sj(o)gren's syndrome

VernacularTitle:原发性干燥综合征与脂代谢紊乱关系初探
Author: Ke XU ; Hua WEI ; Wenpeng ZHAO ; Jinfeng LU ; Fang LI ; Yuehong HUO ; Xiaofeng LI
Publication Type:Journal Article
Keywords: Sj(o)gren's syndrome; Dyslipidemia; Correlation
From: Chinese Journal of Rheumatology 2009;13(1):33-35
CountryChina
Language:Chinese
Abstract: Objective To investigate the lipid profiles of patients with primary Sjogren's syndrome (pSS) and to analyze the correlation between abnormal serum lipids and the inflammationsof SS. Methods One hundred and fourteen pSS patients and 20 gendermatehed healthy controls were studied. Serum lipids were measured in both groups. Results There was statistically significant difference between SS and healthy controls, and the serum HDL-c and apoA<,1 concentrations were significantly lower in patients (P<0.05). The incidence of abnormal serum lipids was 39.5% in these patients. Patients with abnormal lipids had longer course of disease, higher ESR level, lower salivary flow rate and more frequent parotid gland enlargement than those without abnormal lipids(P<0.05). Logistic regression analysis revealed statistically significant association between serum lipids levels and occurrence of parotid gland enlargement. Conclusion Findings from this study suggest that patients with SS have altered lipid profiles and the decrease of apoA, and HDL-c levels may be the correlated factors of SS. The inflammation of SS may cause changes in lipids metabolisms.