Association Between Apolipoprotein E Gene Polymorphism and Cerebral Infarction in Chinese Han Population A Meta-Analysis
- VernacularTitle:载脂蛋白E基因多态性与中国汉族人脑梗死关系的汇总分析
- Author:
Baofeng FANG
;
Zhenzhong LI
;
Hong WANG
;
Cuifang CAO
- Publication Type:Journal Article
- Keywords:
apolipoprotein E;
gene polymorphism;
cerebral infarction;
a meta-analysis
- From:
International Journal of Cerebrovascular Diseases
2008;16(12):888-893
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To systematically review the association between apolipoprotein E (APOE) gene polymorphism and cerebral infarction in Chinese Han population. Methods: The pertinent literature of the gene polymorphism and the case control studies of cerebral infarction in Chinese Han population were researched comprehensively by combined application of 5 effective retrieval approaches. The odds ratio (OR) of the genotype distribution in cerebral infarction group and control group were calculated. Results: A total of 1986 patients with cerebral infarction and controls were included in the meta-analysis. After the data were pooled, the OR values of ApoE ε2/ε3, ApoE ε3/ε3, ApoE ε2/ε4, ApoE ε3/ε4, and ApoE ε4/ε4 were 0. 59 (95% CI, 0.44-0. 79), 0. 52 (95% CI, 0. 40-0.69), 2.00 (95% CI, 1.22-3.28), 2.77 (95% CI, 1.60-4.81 ), and 4. 66 (95% CI, 1.61-13.48), respectively. Conclusions: ApoE ε2/ε4, ApoE ε3/ε4 and ApoE ε4/ε4 genotypes are the risk factors of cerebral infarction. ApoE ε2/ε3 and ApoE ε3/ε3 genotypes are the protective factors of cerebral infarction.
