Hypoxia-inducible factor 1 and endometrial carcinoma
- VernacularTitle:缺氧诱导因子-1与子宫内膜癌
- Author:
Xin LIU
;
Li WANG
;
Huayun TAN
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Anoxia;
Hypoxia inducible factor-1
- From:
Journal of International Oncology
2008;35(12):932-934
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor 1 ( HIF-1 ) can receive and conduct signals under hypoxia,so it participates in the transcriptions of some genes induced by hypoxia.Hypoxia can cause an increasing expression of HIF-1 α in endomettial carcinoma,which might work on angiogenesis,glycometabolism,invasion,prolifera-tion,apoptosis,differentiation and prognosis of tumor.HIF-1α attracts more and more attention in recent years,detection of HIF-1α in endometrial carcinoma may be useful for its therapy.
