Expression of CD24 and FAK in breast carcinoma and their clinical significance
- VernacularTitle:膜糖蛋白CD24和黏着斑激酶在乳腺癌组织中的表达及其临床意义
- Author:
Jianliang ZHUANG
;
Rongjin HUANG
;
Rongyu XU
;
Qunxiong PAN
;
Zijian SU
- Publication Type:Journal Article
- Keywords:
Membrane glycoproteins;
Protein-tyrosine kinase;
Breast neoplasms
- From:
Journal of Chinese Physician
2008;10(12):1619-1622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD24 and FAK in the invasive breast ductal carcinoma tissues and their clin-ical significance. Methods Tissues were obtained from 86 patients with breast carcinoma and 30 non-cancer specimens. The expression of CD24 and FAK was detected by immunohistochemical technique (ElivisionTMPlus) and their correlation with tumor clinicopathological char-acters was analyzed. Results The positive rate of CD24 and FAK expression in 86 cases of breast carcinoma was 87.2% (75/86) and 72.1% (62/86) respectively, which was significantly different from that in control group(P<0.01). Expression of CD24 was significantly correlated with axillary lymph node metastasis(P<0.01). Expression of FAK was correlated with histopathologic grade, axillary lymph node metastasis and clinical stage (P<0.05). There was a positive correlation between the expressions of CD24 and FAK in breast carci-noma tissues (rs = 0.222, P < 0.05). Conclusion Expression of CD24 and FAK are closely correlated with the development of breast carcinoma and there is a markedly positive correlation between CD24 and FAK expression. These indexes can be helpful in understanding the biological behaviors and predicting the prognosis of breast carcinoma.
