Contrast-enhanced ultrasound for the complex cystic focal liver lesions:diagnostic performance and Interobserver agreement
10.3760/cma.j.issn.1004-4477.2009.01.014
- VernacularTitle:超声造影对肝复杂囊性病变的诊断性能和一致性研究
- Author:
Manxia LIN
;
Huixiong XU
;
Mingde Lü
;
Xiaoyan XIE
;
Lida CHEN
;
Zuofeng XU
;
Guangjian LIU
;
Xiaohua XIE
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Liver diseases;
ROC curve
- From:
Chinese Journal of Ultrasonography
2009;18(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic performance of real-time contrast-enhanced ultrasound (CEUS)in characterizing complex cystic focal liver lesions(FLLs).Methods Sixty seven complex cystic FLLs in 65 patients were examined with baseline ultrasound(BUS)and CEUS.BUS and CEUS images were reviewed by a resident radiologist and a staff radiologist independently.Diagnostic performance was evaluated using receiver operating characteristic(ROC)analysis and the interobserver agreement was analyzed by weighted k statistics.Results After ROC analysis,the areas under the ROC curve(Az)were 0.917 for the staff radiologist and 0.774(P=0.044)for the resident radiologist on BUS,and were 0.935 and 0.922(P=0.42)on CEUS.A significant difference in Az between BUS and CEUS was found for the resident radiologist(0.774 versus 0.922,P=0.047),whereas not found for the staff radiologist(0.917 versus 0.935,P=0.38).Better results of specific diagnosis were obtained on CEUS[28.4%(19/67)before versus 58.2%(39/67)after review of CEUS images for resident radiologist,and 26.9%(18/67)versus 76.1%(51/67)for staff radiologist,both P＜0.001].Interobserver agreement was improved after review of CEUS images[K=0.325(95%confidence interval:0.214-0.436)on BUS versus k=0.774(95%confidence interval:0.688-0.860)on CEUS].Conclusions Real-time CEUS improves the capability of discrimination between malignant and benign lesions and specific characterization for complex cystic FLLs,as well as the interobserver agreement.
