Relationships between plasma concentrations of angiotesin Ⅱ,aldosterone and left ventricular remodeling in the patients with chronic heart failure
- VernacularTitle:慢性心力衰竭患者血浆血管紧张素Ⅱ、醛固酮水平与左室重构的关系
- Author:
Jianfeng YANG
;
Liang SHI
;
Jinghan WEI
- Publication Type:Journal Article
- Keywords:
Heart failure;
Angiotensin Ⅱ;
Aldosterone;
Ventfieular remodeling
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):1976-1977
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the olasma concentrations of angiotesin Ⅱ,aldosterone and the parameters that reflected the reconstruction of left ventricular in chronic heart failur(CHF)patients.Methods 61 CHF pmiems and 20 normal control subjects were enrolled.plasma concentration of angiotesin Ⅱ,aldosterone were measured by specific radioimmunoassays.Two dimensional,M-mode and Doppler ultrasound recording were obtalned to determine left vantricular mass index(LVMI),left ventricular ejection fraction(LVEF)and maximal early transmitral flow velocity in diastole(VE)and maximal late transmittal flow velocity(VA).Results Baseline plasma concemrations of angiotesin Ⅱ,aldostemne were increased significantly in CHF patients as compared with normal thme of control group and were paralleled to the increase of NYHA cardiac functional classification of CHF(P＜0.01).Plasma concentrations of angiotesin Ⅱ,aldostemne were positively correlated with LVMI but negatively correlated with VE/VA(P＜0.01).Conclusion Plasma concentrations of angiotesin Ⅱ,aldosterone were increased signifcantly in CHF patients and might be involved in and regulated the reconstruction of left ventricular in CHF patients.
