Effect of high intensity focused ultrasound ablation on microvessel density and vascular endothelial growth factor in rabbit hepatcocellular carcinoma models

VernacularTitle:高强度聚焦超声对兔肝肿瘤微血管密度及血管内皮细胞生长因子的影响
Author: Qiuyang LI ; Xiaodong ZHOU ; Ming YU ; Wen LUO ; Hongling LI ; Zenghui HAN ; Guangbin HE
Publication Type:Journal Article
Keywords: Ultrasonography; Ultrasound,high-intensity focused; Liver neoplasms; Endothelial growth factors
From: Chinese Journal of Ultrasonography 2009;18(1):71-74
CountryChina
Language:Chinese
Abstract: Objective To study the effect of high intensity focused ultrasound(HIFU)ablation on microvessel density(MVD)and vascular endothelial growth factor(VEGF)in rabbit hepatcocellular carcinoma (HCC)models.Methods The VX2 t umor cells were planted in the hepatic left-central lobe on 30 rabbits.All animals were divided into two groups randomly:HIFU group(n=25)and control group(n=5).The MVD and the expression of VEGF in the HCC was detected by immunohistochemical SABC methods in control group and 0,1,3.7,16 d after the operation in HIFU group.Results The MVD and the expression of VEGF in the HCC tissue after HIFU treatment in the HIFU group were decreased significantly as compared with those in the control group (P＜0.01).However,there was no significant difference in MVD and the expression of VEGF in the HCC tissue after HIFU treatment in the HIFU group among the different time points(P＞0.05).Conclusions HIFU treatment can effectively destroy the micovessel,repress the neovascularization and reduce the blood supply of the HCC.