Influence of atorvastatin to TNF-α and IL-10 in intracerebral hemorrhage rats
- VernacularTitle:阿托伐他汀对脑出血大鼠TNF-α和IL-10的影响
- Author:
Ewen TU
;
Jun WU
;
Tao TANG
;
Changang TANG
;
Liming TAN
- Publication Type:Journal Article
- Keywords:
Intmcerebral hemorrhage;
Acute inflammatory reaction;
IL-10;
TNF-α;
Atorvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):1940-1942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the neuroprotective effect of atorvastatin and its influence to tumor necrosis factor-alpha(TNF-α) and intedeukin-10(IL-10)in intraeerebral hemorrhage(ICH)rats,and to explore the possible mechanism of its neuroproteetive effect.Methods ICH WaS induced by stereotaxic infusion of collagenase into the right baSal ganglia,the expressions of TNF-α,IL-10 in the serum and brain tissue were analyzed by enzyme linked immunosorbent assay(ELISA),HE staining was used to evaluate the number of activated microglia.Results (1)The numbers of activated mieroglia,TNF-α and IL-10 were have significant differences between group A and group B(all P＜0.05).(2)In comparision with group B,numbers of activated mieroglia in group C,D and E were significantly redueed(P＜0.05).Atorvastatin cause a dose-dependent regulation,which decreased the level of TNF-α and inereased the level of IL-10 significantly(all P＜0.05).Conclusion The down-regulation of TNF-α and up-regulation of IL-10 might partly attribute to the neuropmtection of atovastatin.
