Effects of pre-operative intraarterial infusion chemotherapy on micro-vessel density in colorectal cancer
- VernacularTitle:动脉灌注化疗对术前大肠癌微血管密度的影响
- Author:
Weidong ZHU
;
Manyue ZHENG
;
Jia LUO
- Publication Type:Journal Article
- Keywords:
Cdoreetal neoplasms/drug therapy;
Micro-vessel density;
Arterial infusion chemotherapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):1950-1951
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal Cancer.Methods 35 patients with colorectal cancer,treated by surgery were divided into two groups randomly.There were 20 patients in group A(pre-operative intra-arterial infusion chemotherapy) and 15 in group B(control).Arterial contrast technique Was used in group A then mitromye in 10mg,5-Fu 1000mg epirubic in 60mg were given through Weidner way-Results Microveasel density in the center,surface of the tumor and adjacent tissue around the tunlor were (40.46±7.06),(52.27±18.40),(49.92±8.15) in group A,and (46.09±12.21),(73.44±22.06),(51.94±12.64)in group B.Microvessel density on the surface in group A was significantly lower than that of group B(P＜0.05),with no significance between the center and the adjacent tissue.Conclusion Pre-operative intraarterial infusion chemotherapy is able to reduce micro-vessel density on the surface of eolorectal tumor.
