The expression of bFGF and microvessel density in non-small cell lung cancer
- VernacularTitle:bFGF mRNA 和蛋白在非小细胞肺癌表达与微血管密度测定的临床意义
- Author:
Qiongchuan HONG
;
Jianguo WU
;
Yong ZHAO
;
Chengfang MA
;
Yanling TAO
- Publication Type:Journal Article
- Keywords:
NSCLC;
Fibroblast growth factor;
Microvessel density
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):2006-2007
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of basic fibroblast growth factor (bFGF) and microvessel density(MVD)in non-small cell lung cancer.Methods The expression of bFGF and MVD were observed in 54 eases of NSCLC were detected with in situ hybrldization and immunohistochemical detection.Resuits The expression of bFGF and MVD was greater in adenecarcinomas than in squamous cell carcinomas of NSCLC (P＜0.05).The expression of bFGF was significantly different among the three groups of both squamous cell carcinomas and adenocarecnomas with varying differentiation (P＜0.05).There was hisher bFGF expression and greater MVD in NSCLC patients with regional lymplmode involvement and those with laterdistant metastasis(P＜0.05).Condusion bFGF may play an important role in tumor angiogenesis and lymphatic metastasis of human NSCLC,and detection of bFGF may be a good metastasis and prognostic predictors for human NSCLC.
