Bβ Fibrinogen Gene Polymorphisms and Ischemic Cerebrovascular Disease
- VernacularTitle:纤维蛋白原Bβ基因多态性与缺血性脑血管病
- Author:
Qiwen HUO
;
Feng TAN
- Publication Type:Journal Article
- Keywords:
fibrinogen;
gene polymorphism;
ischemic cerebrovascular disease
- From:
International Journal of Cerebrovascular Diseases
2008;16(12):943-946
- CountryChina
- Language:Chinese
-
Abstract:
The increased level of fibrinogen (Fg) is an independent factor that resulting in the occurrence of ischemic cardio-cerebrovascular diseases. The Fg level is correlated with heredity, age, sex, obesity, lipid, smoke, inflammation and infection, and the pathogenic effect of genetic factor has been increasingly receiving attention. In recent years, more than 10 FgBβ gene polymorphisms have been reported, among them, - 148C/T, - 455G/A, and - 854G/A are considered to be significantly correlated with the increased level of Fg, and may be one of the most key factors in influencing the genetic risk factors of the occurrence of ischemic cerebrovascular disease.
