Efficacy of expulsive therapy using tamsulosin and diclofenac suppository for distal ureteral stones
- VernacularTitle:坦索罗辛联合双氯芬酸钠栓治疗下段输尿管结石的随机对照临床研究
- Author:
Xiqing GUI
;
Zhenyu GUO
;
Huabin SUN
;
Wenfei LIAN
;
Lukun YANG
- Publication Type:Journal Article
- Keywords:
Tamsulosin;
Diclofenae suppository;
Distal ttreteral;
Calculi
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(12):1982-1984
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of expulsive therapy using alpha 1-selective adrenoblocker and prostaglandin synthetase inhibitor for distal ureteral stones.Methods 94 patients with distal ureteral stone were randomly divided into study group and control group.In study group,47 cases received tamsulosin 0.2mg daily and dielofenac rectal suppositories 50mg 2 times daily,while watchful waiting without tamsulosin and diclofenac suppository in 47 cases of control group.Observation lasted 2 weeks and also stone expelled as end point.Results No severe adverse reactions related to the drugs were noted and no patients withdrew from the study.The stone-free rate was 91.5%(43/47) of the study group and 25.5% (12/47) of the control group (P＜0.01).A mean stone expelling date of the control group was(8.9±4.3)d and that of the study group was(6.4±3.7)d(P＜0.01).Rates of renoureteral colic recurred in the study group and the control group were 4.3%(2/47) and 48.9%(23/47),respectively (P＜0.01).Conclusion Treatment of distal ureteral stones wlth tamsulosin and dielofenac suppository can increase the stone-free rate,shorten mean stone expelling date,decrease rate of renottreteral colic recurred.
